Advertising revenue supports our not-for-profit mission. All rights reserved. Before you begin treatment with suramin, you and your doctor should talk about the good suramin will do as well as the risks of receiving it. It is important that your doctor check your progress at regular visits. No serious side effects Suramin is used in the treatment of African sleeping sickness (African trypanosomiasis) and river blindness (onchocerciasis), infections caused by parasites. Adults and children—Dose is based on body weight and must be determined by your doctor. This is to help make sure that the infection is cleared up completely. (Left) A colorized transmission electron micrograph of cellular mitochondria, which produce a small molecule called ATP. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. These side effects can be serious and include neuropathy, anaemia, and adrenal insufficiency. They soon realized that Suramin’s properties exhibited … We comply with the HONcode standard for trustworthy health information -, Liver disease—Patients with kidney or liver disease may have an increased chance of side effects. Larger, carefully designed clinical trials are needed to replicate the results, learn how to use low-dose suramin safely in autism, identify drug interactions as well as detect rare side effects and collect all the data that the FDA requires to approve the use of suramin in autism. The amount of medicine that you take depends on the strength of the medicine. CONCLUSION: These results demonstrate the efficiency of suramin in vitro to inhibit migration of HLEC which can be explained by blocking growth factor-mediated effects on the cells. These effects include diarrhea, headache, nausea, skin tingling, vomiting, and weakness. See "What Are Side Effects Associated with Using Suramin?" In these cases, your doctor may want to change the dose, or other precautions may be necessary. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Metabolic- Adrenal insufficiency and abnormality in liver enzymes. Skin- Rash and itching. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Along with its needed effects, a medicine may cause some unwanted effects. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Rate Suramin to receive MedCheck, Discover best treatments based on user reviews of side effects, efficacy, health benefits, uses, safety and medical advice. Suramin works by causing the parasites to lose energy, which causes their death. Your doctor may also want to check for any side effects that may occur even after your treatment has ended. Before you begin treatment with this medicine, you and your doctor should talk about the good this medicine will do as well as the risks of receiving it. For suramin, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to suramin or any other medicines. This site complies with the HONcode standard for trustworthy health information: verify here. Suramin has been shown to benefit men with disease that has become resistant to hormone therapy, but proved to have too many side effects when combined with hormone therapy as an initial, first-line treatment for advanced prostate cancer. In the present study, Standard chemotherapy regimens for Chagas disease pos- we investigated under standardised conditions the in vitro sess limited efficacy during the acute and chronic phases and activity of suramin against T. cruzi, taking into account the produce serious side effects. If you notice any other effects, check with your healthcare professional. [4] Suramin causes a fair number of side effects. The suramin trial was a notable success. Check with your doctor as soon as possible if any of the following side effects occur: More common. Gastrointestinal- Vomiting, abdominal pain, nausea and metallic taste. Larger clinical trials will be needed to detect uncommon side effects. We were unable to detect rare side effects that might affect fewer than twenty percent (1 in 5) patients. If left untreated, these sores may lead to life-threatening infections. Suramin is a medication used to treat African sleeping sickness and river blindness. Again, it must be remembered that only a single low dose of suramin was used in the study [4] There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. You may report side effects to the FDA at 1-800-FDA-1088. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. And suramin, at this stage, is not the ultimate answer. Check with your doctor as soon as possible if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. Data sources include IBM Watson Micromedex (updated 3 Mar 2021), Cerner Multum™ (updated 1 Mar 2021), ASHP (updated 3 Mar 2021) and others. Suramin caused a self-limited, asymptomatic rash, but this disappeared without treatment in 2-4 days. Proteinuria and renal toxicity reported with use; Avoid use in renal or hepatic impairment; Pregnancy and Lactation. Naviaux explained that the vast majority of side effects seen with Suramin come when it’s used at cancer chemotherapy doses 25x’s higher than used in his study. Long-Term Effects. Adults—Dose is based on body weight and must be determined by your doctor. Objectives: Suramin, a polysulfonated naphtylurea with anti-growth factor activity, was used in the treatment of metastatic, hormone- and chemotherapy-refractory prostate cancer. For non-prescription products, read the label or package ingredients carefully. The later phase of drug therapy may cause kidney damage and exfoliative dermatitis. What are the side effects of Suramin? The side effects of suramin were minimal in the study and included the development of rash. These side effects are with long-term use and higher doses of the drug. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Drugs & Diseases. This content does not have an English version. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Suramin may cause serious side effects. Seek immediate medical care if you experience any of these reactions. The immunosuppressive effect of suramin may i … The users guide to prescription drugs and supplements: Finding the right medication is important Let RateADrug help. Figure 2: Synthetic derivatives and analogues of suramin 1. Suramin is administered in the hospital only by or under the immediate supervision of your doctor. The pills contained either 1.5, 4 or 10 milligrams of balovaptan or a placebo. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. Elderly people are especially sensitive to the effects of suramin. All five developed a mild rash but experienced no other health problems, researchers reported in May in the Annals of Clinical and Translational Neurology 1. Therefore, it is especially important that you discuss with the child's doctor the good that suramin may do as well as the risks of receiving it. However, further investigations on the pharmacokinetic properties of suramin and possible side-effects on other intraocular tissues must follow. One caveat however about side-effects is that our study was small and only 5 boys received suramin. View chapter Purchase book But suramin is not a benign medication. © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). More seriously, it can also cause kidney damage in some individuals, and is generally not prescribed to those with existing renal problems. It is the treatment of choice for sleeping sickness without central nervous system involvement. Methods: Between March 1990 and January 1994, 27 patients with metastatic prostate cancer were enrolled in this study. You may report side effects to the FDA at 1-800-FDA-1088. All rights reserved. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. Call your doctor for medical advice about side effects. • Skin : Rash and itching. The majority of the side effects listed below are based on suramin's use as an antiprotozoal agent. crawling or tingling sensation of the skin, faintness, especially after missing meals, numbness or weakness in arms, hands, legs, or feet, painful tender glands in the neck, armpits, or groin, swelling and/or tenderness in upper abdominal or stomach area. There is currently no evidence that lower amounts of curcumin cause serious side effects in humans when taken over short periods, though human studies on the long-term effects are lacking. Thus, its serious side effects are already known and can include neuropathy, anemia and adrenal insufficiency. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. An important side effect observed in pa- tube. The dose of suramin will be different for different patients. Larger clinical trials will be needed to detect uncommon side effects. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. 5A. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. The use of this drug has been recommended only under medical supervision. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Suramin was given to ten outpatients with acquired immunodeficiency syndrome (AIDS) presenting as Kaposi's sarcoma (KS) or as an AIDS-related complex (ARC). Larger clinical trials will be needed to detect uncommon side effects. Check with your doctor as soon as possible if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. Funding was entirely from private donations. If you notice any other effects, check with your healthcare professional. • Central nervous system : Fever, headache, tiredness, fainting, weakness, numbness and increased sensitivity in hand and foot. This content does not have an Arabic version. Children—Use and dose must be determined by your doctor. Although not all of these side effects may occur, if they do occur they may need medical attention. There have been no human studies conducted of suramin use during pregnancy. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Follow your doctor's orders or the directions on the label. Suramin alone presents background noisy ef- tients treated with suramin is an anticoagulant state fects with no ellipticity above 270 nm as shown in that is, in part, attributed to direct inhibition of several Fig. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. The catch is that suramin has already been used in people for a long time. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. It is given by injection into a vein. Suramin is a medication used to treat African sleeping sickness and river blindness. towards liver and kidney. Suramin treatment can lead to a number of potential side effects, most commonly nausea, vomiting, and an itchy rash. Mayo Clinic facts about coronavirus disease 2019 (COVID-19), Our COVID-19 patient and visitor guidelines, plus trusted health information, Mayo Clinic Health System patient vaccination updates. Also, contact your doctor if you have any of the following severe side effects: Call your doctor for medical advice about side effects. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Cloudy urine crawling or tingling sensation of the skin diarrhea faintness, especially after missing meals headache increased skin color irritability itching joint pain loss of appetite nausea Along with its needed effects, a medicine may cause some unwanted effects. Cautions. Suramin inhibits the signaling function of ATP, eliminating the cell danger response associated with autism. Suramin side effects Central nervous system- Fever, headache, tiredness, fainting, weakness, numbness and increased sensitivity in hand and foot. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Suramin can cause serious side effects in any patient. Side effects. Copyright © 2021 IBM Watson Health. If your dose is different, do not change it unless your doctor tells you to do so. Side-effects associated with the administration of 6.2 g of suramin over 5 weeks included fevers, rashes, urinary abnormalities, and transient rises in hepatic aminotransferases. These side effects may go away during treatment as your body adjusts to the medicine. Make sure you tell your doctor if you have any other medical problems, especially: To help clear up your infection completely, you must receive suramin on a regular schedule for the full time of treatment. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer — Mayo Clinic Health Letter, Time running out - 40% off Online Mayo Clinic Diet ends soon. Medical attention interactions may occur, if they do occur they may need attention! Immediate medical care if you are taking any other effects, check interactions and set up your personal. January 1994, 27 patients with metastatic prostate cancer were enrolled in this study treatment in 2-4 days go during... About ways to prevent or reduce some of these side effects during treatment as your body to! Is generally not prescribed to those with existing renal problems adequate studies in women for determining infant risk Using., nausea and metallic taste not previously been reported to occur with suramin therapy, occurring 13! Or tobacco or the directions on the label or package ingredients carefully OTC ] ) medicine no adequate studies women... Medication records view chapter Purchase book ( Left ) a colorized transmission electron micrograph of cellular mitochondria, causes! Causes a fair number of side effects to the Terms and Conditions and Privacy Policy linked.. Pain, nausea, vomiting, and an itchy rash rash,,. May report side effects may occur even after your treatment has ended: Fever, joint pains, photophobia peripheral... And disseminated superficial actinic porokeratosis have not previously been reported to occur suramin! Used at or around the time of eating food or eating certain types of food since interactions may occur if. 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